Research - some results

Modeling for cardiac electrophysiology (Inria, IHU Liryc)
My main research topics in Carmen follow two axes:
  • Modeling of subcellular biological mechanisms in cardiomyocytes, and mathematical homogeneization and/or numerical inclusion of these models at the macroscopic scale.
  • Modeling for improvement of cardiac ablation techniques (RF, electroporation) and cardiac stimulation (pacemakers).
 
A lot of my time has been dedicated to the development of the CEPS software, for simulations of cardiac electrophysiology. You can download it on Codeberg, and contribute!
Electropermeabilization (PhD Inria MONC)
  • Electric field in a cell submitted to high-voltage pulse and change in the membrane surface conductance, where the transmembrane potential difference gets close to a voltage threshold.



  • Qualitative comparison between experimental intake of Propidium Iodide by CHO3 cells (Escoffre et al. 2003) and simulations.

     


  • Influence of lipids diffusion on membrane surface: higher pulse frequencies lead to lower permeability.

Helioseismology (Post-doc @MPS)
  • Propagation of a solar acoustic wave excited by a point source at the north pole. The simulated power spectrum used to generate this video matches observations satisfactorily.